The Australian Animal Disease Spread Model (AADIS) is Australia’s official decision support tool for emergency animal diseases such as foot-and-mouth disease, African swine fever, lumpy skin disease, and avian influenza. AADIS is a critical tool for government and industry to prepare for, and respond to, outbreaks of emergency animal disease. It combines mathematical, agent-based, network, and cellular automata modelling approaches to represent the incursion, detection, surveillance, control, and proof-of-freedom of emergency animal disease. Developed in Australia for Australia, it has since been adapted for use by animal health authorities in over 20 countries.