The Australian Animal Disease Spread Model (AADIS) is Australia’s official decision support tool for emergency animal diseases such as foot-and-mouth disease, African swine fever, lumpy skin disease, and avian influenza. AADIS is a critical tool for government and industry to prepare for, and respond to, outbreaks of emergency animal disease (EAD). It combines mathematical, agent-based, network, and cellular automata modelling approaches to represent the incursion, detection, surveillance, control, and proof-of-freedom of emergency animal disease. AADIS helps governments assess the cost effectiveness of response strategies both prior to and during an outbreak of EAD. Developed in Australia for Australia, it has since been adapted for use by animal health authorities in over 20 countries.